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I have been suffering from anemia for more than 6 years now. I have bloodclots that went into my eyes, because of them I lost most of the sight in my right eye. Our family doctor said that my eyesight might never come back but I decided not to give up. I have my laser treatment every 2 weeks. He prescribed me with Epogen and the drug has greatly improved my condition. My eyesight is better and I'm not in panic anymore. In addition my general symptoms have gone milder; I don't get tired that easily and don't look too pale. Epogen is great for me.
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In 2004, before completion of the CHOIR trial, Amgen approached the FDA during the planning of the Trial to Reduce Cardiovascular Events with Aranesp Therapy (TREAT) (ClinicalTrials.
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Serious adverse events were defined as life-threatening, resulting in death, hospitalization, or substantial disability, or leading to a congenital anomaly or birth defect.
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In addition, the adjudication process by the committee reviewing clinical end points should have attenuated the possibility of bias because committee members were unaware of patients' study-group assignments.
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For rapid digitalization, initial dose is higher than maintenance dose; 50% of total digitalizing dose is given initially.
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In contrast, homologous blood is possible to detect because of the presence of mismatched RBC blood group antigens.
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