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However, because each study found different NPC1L1 and haplotypes to be associated with ezetimibe response, it is as of yet unclear which polymorphism(s) is actually underlying altered response.

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For patients prone to glycemic variability, especially type 1 diabetic patients or type 2 diabetic patients with severe insulin deficiency, glycemic control is best evaluated by the combination of results from self-monitoring and the A1C.

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Select “No” for Documented Contraindications or Warnings for not initiating IV thrombolytic in the 0-3hr treatment window?

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Therapeutic Management of Familial Hypercholesterolemia: Current and Emerging Drug Therapies.

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Note from the National Kidney Foundation (NKF) and the National Guideline Clearinghouse (NGC): The 2012 update to the Kidney Disease Outcomes Quality Initiative (KDOQI) Clinical Practice Guideline for Diabetes and CKD provides updated recommendations for management of hyperglycemia, dyslipidemia, and albuminuria in individuals with diabetes mellitus and chronic kidney disease (CKD).

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Large-Scale Single-Nucleotide Polymorphism (SNP) and Haplotype Analyses, Using Dense SNP Maps, of 199 Drug-Related Genes in 752 Subjects: the Analysis of the Association between Uncommon SNPs within Haplotype Blocks and the Haplotypes Constructed with Haplotype-Tagging SNPs.

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Among the oral antidiabetic agents, metformin and acarbose are classified as category B and all others as category C; potential risks and benefits of oral antidiabetic agents in the preconception period must be carefully weighed, recognizing that sufficient data are not available to establish the safety of these agents in pregnancy.

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Refer to statin label for details about who should not take that statin.

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Five simple clinical tests (use of a 10-g monofilament, vibration testing using a 128-Hz tuning fork, tests of pinprick sensation, ankle reflex assessment, and testing vibration perception threshold with a biothesiometer), each with evidence from well-conducted prospective clinical cohort studies, are considered useful in the diagnosis of LOPS in the diabetic foot.

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Most cases of rhabdomyolysis occurred in patients receiving statin therapy prior to initiating ezetimibe; however, rhabdomyolysis also reported very rarely following ezetimibe monotherapy or following addition of ezetimibe to therapy with agents known to be associated with increased risk of rhabdomyolysis (e.

The aim of this investigation is the benefit assessment of treatment with ezetimibe (in mono- or combination therapy) compared to treatment with placebo or other lipid-lowering drugs, as well as to non-drug treatment options in patients with hypercholesterolaemia.

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Pharmacogenetic association between ALOX5 promoter genotype and the re-sponse to anti-asthma treatment.

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If sources other than a laboratory report document discrepant LDL-c values for the same specimen, use the highest value.

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Ultimately, the study found no significant difference in the study's primary endpoint between those taking the combination drug and those taking placebo.

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Effect of ETC-1002 on Serum Low-Density Lipoprotein Cholesterol in Hypercholesterolemic Patients Receiving Statin Therapy.

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Conclusive evidence that NPC1L1 is the target of ezetimibe was provided by studies with tissues from NPC1L1-deficient mice.

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Effect of Daily Glucose Fluctuation on Coronary Plaque Vulnerability in Patients Pre-Treated With Lipid-Lowering Therapy.

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Each year, this monitoring may generate many thousands of analyses of associations between a treatment and an unrelated outcome.

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Effect of angiotensin-converting enzyme (ACE) gene polymorphism on progression of renal disease and the influence of ACE inhibition in IDDM patients: findings from the EUCLID Randomized Controlled Trial: EURODIAB Controlled Trial of Lisinopril in IDDM.

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You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment.

Use of ezetimibe results in more patients reaching lipid targets without side effects.

The management plan should be formulated as an individualized therapeutic alliance among the patient and family, the physician, and other members of the health care team.

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Change in effect of vitamin C on FDD after 4 weeks of therapy with simvastatin or ezetimibe (vs before treatment).

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There was no evidence that the presence of anti-drug binding antibodies impacted the pharmacokinetic profile, clinical response, or safety of REPATHA, but the long-term consequences of continuing REPATHA treatment in the presence of anti-drug binding antibodies are unknown.

Statin Therapy in Patients With Chronic Kidney Disease Undergoing Percutaneous Coronary Intervention (from the Evaluation of Drug Eluting Stents and Ischemic Events Registry).

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This LDL-cholesterol mortality paradox, as shown in Figure 1 Odds Ratios for Mortality, According to Treatment for Cardiovascular Disease in Six Major Trials.

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Delayed Imatinib Treatment for Acute Spinal Cord Injury: Functional Recovery and Serum Biomarkers.

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Food and Drug Administration today approved Kynamro (mipomersen sodium) injection as an addition to lipid-lowering medications and diet to treat patients with a rare type of high cholesterol called homozygous familial hypercholesterolemi".

The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit.

The updated information was verified by the guideline developer on August 9, 2013.

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