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Las companías fármacas que producen las versiones genéricas, solamente deben comprar una fórmula química y gastar dinero en la producción.
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He received his medical degree in 1982 and his Ph.

Whilst impressive clinical benefits have been observed for NSCLC with a known driver mutation, acquired resistance is frequently seen and presents us with the next challenge in the goal to deliver unique personalised medicine.

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The most robust data is seen in the six trials that evaluated either erlotinib or gefitinib (epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs)) as switch maintenance.

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In patients with resistance to first-generation EGFR TKIs generated by MET amplification, it is unlikely that an irreversible EGFR inhibitor alone would be effective, but the combination of an irreversible EGFR inhibitor and an mTOR inhibitor may be an effective strategy for overcoming resistance ().

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This correlates with our observation that these clones exhibit the highest levels of GTP-bound KRAS ().

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The aim of the present work was to examine the effects of a combined treatment of metformin with gefitinib, a selective EGFR-TKI on NSCLC cell lines.

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Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: a Southwest Oncology Group Study.

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In May 2011, the USFDA approved Sunitininb for treating patients with 'progressive neuroendocrine cancerous tumors located in the pancreas that cannot be removed by surgery or that have spread to other parts of the body (metastatic)'.

The simulation process was conducted in a sequential manner, initially using the PK model to generate the AUC t values for each selected dose regimen, which subsequently defined the PD variables (IC 50 and K tr) via the functional equations (see Supplementary Fig.

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TLG-S criteria are superior to both EORTC and PERCIST for predicting outcomes in patients with metastatic lung adenocarcinoma treated with erlotinib.

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Debido a que este es muy probablemente el resultado de una reducción en el error de estadificación, es decir, una disminución de la probabilidad de pasar por alto los ganglios linfáticos positivos con un número cada vez mayor de muestras de ganglios linfáticos, se indica que una evaluación del estado ganglionar debe incluir entre 11 y 16 ganglios linfáticos.

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These results suggested that crosstalk between ectopic human EGFR and endogenous signaling proteins may occur in the transgenic mice.

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